BackgroundThe ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines are widely endorsed but compliance is limited. We sought to determine whether journal-requested completion of an ARRIVE checklist improves full compliance with the guidelines.MethodsIn a randomised controlled trial, manuscripts reporting in vivo animal research submitted to PLOS ONE (March–June 2015) were randomly allocated to either requested completion of an ARRIVE checklist or current standard practice. Authors, academic editors, and peer reviewers were blinded to group allocation. Trained reviewers performed outcome adjudication (...) in duplicate by assessing manuscripts against an operationalised version of the ARRIVE guidelines that consists 108 items. Our primary outcome was the between-group differences in the proportion of manuscripts meeting all ARRIVE guideline checklist subitems.ResultsWe randomised 1689 manuscripts (control: n = 844, intervention: n = 845), of which 1269 were sent for peer review and 762 (control: n = 340; intervention: n = 332) accepted for publication. No manuscript in either group achieved full compliance with the ARRIVE checklist. Details of animal husbandry (ARRIVE subitem 9b) was the only subitem to show improvements in reporting, with the proportion of compliant manuscripts rising from 52.1 to 74.1% (X2 = 34.0, df = 1, p = 2.1 × 10−7) in the control and intervention groups, respectively.ConclusionsThese results suggest that altering the editorial process to include requests for a completed ARRIVE checklist is not enough to improve compliance with the ARRIVE guidelines. Other approaches, such as more stringent editorial policies or a targeted approach on key quality items, may promote improvements in reporting. (shrink)

The standard representation of the Central Dogma (CD) of Molecular Biology conspicuously ignores metabolism. However, both the metabolites and the biochemical fluxes behind any biological phenomenon are encrypted in the DNA sequence. Metabolism constrains and even changes the information flow when the DNA‐encoded instructions conflict with the homeostasis of the biochemical network. Inspection of adaptive virulence programs and emergence of xenobiotic‐biodegradation pathways in environmental bacteria suggest that their main evolutionary drive is the expansion of their metabolic networks towards new chemical (...) landscapes rather than perpetuation and spreading of their DNA sequences. Faulty enzymatic reactions on suboptimal substrates often produce reactive oxygen species (ROS), a process that fosters DNA diversification and ultimately couples catabolism of the new chemicals to growth. All this calls for a revision of the CD in which metabolism (rather than DNA) has the leading role. (shrink)

Our goal is to use prototype analysis to distinguish the folk or culturally held understandings of love, romantic love, and sex and to specify, from the obtained data, the semantic relationship among these three associated concepts. By considering the semantic distinctions between these three concepts, we come to an unintended insight: if romantic love is a socio-cultural universal it does not appear to have the same evolutionary history as love or sex and this may account for its somewhat ambiguous status (...) in the scholarly literature on romantic love. We demonstrate that, in the United States, sex, in and of itself, is seldom conceived of as a relationship while love and romantic love are primarily viewed as relational. Our findings, though preliminary, strongly suggest that romantic love is a synthesis of two evolutionary drives: love and sex. (shrink)

La oveja (Ovis aries) es el primer animal domesticado para consumo en un hito histórico que marca el inicio de la sedentarización de las comunidades humanas al comienzo del Neolítico. Durante milenios, fueron semejantes al muflón asiático (Ovis orientalis), su ancestro salvaje. Las razas primitivas supervivientes en el norte de Europa son oscuras, mudan el pelo estacionalmente, tienen cuernos en ambos sexos y apenas producen lana. Los ancestros de las modernas surgieron hace unos 3.500 años. Se seleccionaron para producir lana (...) blanca, que crece indefinidamente y se colecta anualmente. Este proceso coincide con la invención de las tijeras de esquilar y con el descubrimiento de tintes como la púrpura. Solo la lana blanca puede teñirse de cualquier color, permitiendo trasladar al tejido las mismas señales que quizá antes nos pintábamos con ocre sobre el cuerpo. La oveja, un herbívoro social muy manejable, sumaba al suministro de alimento el de una fibra abrigada y modificable en su color distintiva de quienes la visten. Un lienzo en blanco donde trasponer las expresiones estéticas antes restringidas al cuerpo, al arte rupestre y al mobiliar. De ahí que diversas mitologías contemplen una relación simbólica especial con ellas. La revolución estética propiciada por las ovejas blancas zozobra en el siglo XX con la aparición de nuevas fibras y el abaratamiento de otras. Hoy, los arquetípicos y blancos rebaños característicos de la iconografía occidental tienden a una coloración mixta al devaluarse la lana. Otras especies domésticas con fibras que solo recientemente se han apreciado comercialmente, como las cabras de angora (Capra hircus) o las llamas (Lama glama), siguen un proceso idéntico al emprendido con las ovejas hace milenios para tornarse blancas. Presentamos las implicaciones estéticas que han estimulado la selección artificial de ovejas con lanas blancas desde un punto de vista transdisciplinar. Siguiendo la corriente bioevolutiva, que entiende nuestra conducta estética y sus manifestaciones como parte de nuestra etología, veremos cómo ese largo proceso estuvo incentivado por nuestro deseo de teñir los tejidos para expresar un fenotipo extendido creando una nueva señal social. Esa nueva señalización, operante en el plano de la selección sexual, se va complicando al desarrollarse nuestras capacidades simbólicas y tecnológicas, siendo sintomática del entorno causal en el que se produce. (shrink)

This article discusses the preponderance of aesthetic aspects within the sport experience, especially as these are reflected in the dialogue between sport and cinema and in relations established via the use of images and the emergence of new ideas of the body at the beginning of the twentieth century. The paper is divided into three parts. The first part identifies points of connection between sport and cinema. The remaining parts interpret the meaning of these connections. The paper concludes that it (...) is important to recognize that sport is not only a theme for art but also a language that establishes inter-semiotic dialogues, something that is deeply characteristic of sport and a source also of its aesthetic meaning. (shrink)

In the last third of the 20th century, the social dynamic in the Ecuadorian Andes was subject to a series of significant changes : the emergence of a powerful Indian movement, on the one hand, and the reconfiguration of the role of the State, as a corollary of the implementation of structural adjustment policies, better known as “Washington Consensus”, on the other. In spite of the strengths of an Indian movement that found its roots in the agrarian reform of the (...) 1960s and 1970s, it became clear that the new neoliberal matrix led to the dissociation of rural development problem from the yet to be solved question of the concentration of land and wealth. By placing the emphasis on the politics of identity and on the organizational aspects of the Indian and peasant issue, the champions of ethno-development have downgraded any reference to the socioeconomic and political claims of the peasant populations. (shrink)

State derecognition, defined as the withdrawal of recognition from a putative state, has been more impactful as a diplomatic subculture in the last decades than is often assumed. Recent practice suggests that when states engage in derecognition, they do not mechanically assess whether a state no longer fulfils the traditional criteria for statehood, but rather employ derecognition as a tool of foreign policy, tailored to enhance their own economic and geopolitical interests. The bargaining dynamics of derecognition and “rental recognition” policies (...) adopted by a range of smaller states create a precarious hostage-like situation for the targeted entities who helplessly watch their international status being traded in a recognition market. As the success of some claims to statehood risks beings reduced to a matter of pricing, a process of commodification emerges: state recognition is granted to the “highest bidder” regardless of factual reality or legal considerations. With this backdrop, the present paper seeks to clarify how international law conceptualizes derecognition and its hypotheses of legality, offering an overview of contemporary events of derecognition and expedient shifts in recognition to clarify the role and deficiencies of international law as it stands before the emerging phenomenon of “statehood commodification”. (shrink)

English summary: Gilduin (1155) was, from 1113, the first abbot of the community of the Canons Regular of St Augustine, soon to become an abbey, under the auspices of St Victor of Marseille, on the left bank of the river Seine. After the death of his confrere Hugh, who was of German descent and the leading figure of the Victorines, on 11 February 1141, abbot Gilduin took care that the writings of Hugh were collected and compiled in a representative complete (...) edition. This 'Gilduin-edition' - as it is called in Medieval scholarship - comprises four volumes, the first of which is reconstructed herewith and presented in print. This volume follows the 2008 edition of Hugh's theological summa, De sacramentis christiane fidei. Then as now we are dealing with a critical albeit historical text. This new volume contains nine works, among which the first ever complete edition of Hugh's Cronica surely stands out. German description: Gilduin (+ 1155) war ab 1113 der erste Abt der einige Jahre zuvor gegrundeten und bald zur Abtei erhobenen Gemeinschaft von Augustinerchorherren unter dem Patronat des hl. Victor von Marseille, auf dem linken Ufer der Seine. Nach dem Tode seines Mitbruders Hugo, des aus Deutschland stammenden fuhrenden Kopfes der Viktoriner, am 11. Februar 1141 hat Abt Gilduin dafur gesorgt, daa die Schriften Hugos gesammelt und in einer reprasentativen Gesamtausgabe zusammengestellt werden. Diese in der internationalen mediavistischen Forschung so genannte,Gilduin-Ausgabe' der Werke Hugos von Saint-Victor umfaat vier Bande, deren erster hiermit rekonstruiert und im Druck vorgelegt wird. Dieser Band folgt somit auf unsere im Jahre 2008 besorgte Ausgabe der theologischen Summe Hugos, De sacramentis christiane fidei. Damals wie heute handelt es sich um einen kritischen, wenngleich historischen Text. Dieser neue Band umfaat neun Werke, unter denen insbesondere die uberhaupt erste vollstandige Ausgabe von Hugos Cronica hervorzuheben ist. (shrink)

O objetivo deste ensaio é analisar as condições de possibilidade da escravidão e da violência antinegra, assim como da produção de significações raciais – do ser-negro – e das fantasias coloniais. Para isso, buscarei, majoritariamente, recursos conceituais na obra de Achille Mbembe, com auxílio de alguns conceitos de Jacques Rancière, de forma a tratar o que chamo de _partilha colonial do sensível_, analisando a relação entre a raça enquanto construção imaginária, significações raciais e a organização social da percepção e da (...) sensibilidade que herdamos do colonialismo europeu. Assim, pretendo elaborar o sentido da ausência de enlutabilidade – nos termos de Judith Butler – e de crises éticas – nos termos de Denise Ferreira da Silva – na esteira da violência racial desde o tempo da escravidão, mostrando, também, como o tempo da liberdade não se constitui como ruptura profunda, pois não interditou a reorganização da linguagem e da imaginação sobre um mesmo fundo de negatividade inaugurado com o exercício soberano do poder colonial como um poder de não-ver e não-ouvir a humanidade negra. (shrink)

RESUMO Com base na noção de currículo como uma arena de embates discursivos, este artigo tem por objetivo principal analisar de que modo a Base Nacional Comum Curricular de Língua Portuguesa e Literaturas compreende os conceitos de fruição e de leitor-fruidor. Com efeito, é nossa intenção compreender como a ideia de leitura literária é proposta por esse documento oficial curricular. Para tanto, as habilidades e conteúdos indicados pela Base Nacional Comum Curricular foram analisados a partir de uma perspectiva metodológica interpretativista (...) e sob a perspectiva dialógica de análise do discurso desenvolvida pelo Círculo de Bakhtin. ABSTRACT Based on the notion of curriculum as an arena of discursive clashes, this paper aims at verifying how the Base Nacional Comum Curricular [Common Core] for Portuguese Language and Literature understands the concepts of fruition and reader-in-fruition. Indeed, it is our intention to understand the very idea of literary reading proposed by this official curriculum document. For this purpose, the skills and contents indicated by BNCC were analyzed from an interpretive research methodology view and under the dialogic perspective for discourse analysis developed by the Bakhtin Circle. (shrink)

This paper addresses first the appticability of the main notions included in the general notion meant item, meant partial situation , meant activity , and implicitly meant background situation -that of meant agent will be only mentioned in an aside-, plus the notion meaning activity . It will be shown that, when coupled to other notions, such as ‘ontological status’ of IMBST relative to the focussed current situation , as well as to the matching ‘ontological’ properties of the meant items (...) above, they allow to set up unified and apparently successful methods to explore important and debated pragmatic issues. Then their usefulness for research in the domain traditionally accorded to speech-act theory is put to test; and finally the general processual sketch of linguistic activity advanced in the last Sections of P.I is carefully gauged as to its prospects regarding actual implementation of more specific processual sketches of both emission and reception linguistic activities. (shrink)

O objetivo deste texto é apresentar e explorar uma imagem de Wittgenstein que ainda permanece nas margens da produção acadêmica de comentários sobre seus escritos: a imagem de um filósofo que não se ocupa de teses e teorias filosóficas, mas de um conflito com sua herança filosófica e com o mundo que habita. Um conflito que não termina, que nos exibe ambiguidades que não são abandonadas através de soluções definitivas para o que assombra o filósofo. As vozes de Wittgenstein nos (...) falam tentações e formas hegemônicas de pensar a filosofia que ainda se fazem presentes, de questões que ainda podem ser colocadas para as comunidades filosóficas, e isso nos leva a pensar que pertinência ainda pode haver em sua demanda por um procedimento terapêutico. Nesse sentido, alguns assuntos serão tratados como: a filosofia como uma forma de terapia antifilosófica, a relação entre a “doença de uma época” e os escritos e aspectos biográficos de Wittgenstein, o desejo de autenticidade e a possibilidade de soluções individuais para os problemas relativos à “escuridão desta época”. (shrink)

Peut-être l’un des mots les plus forts pour résumer les politiques mises en place pour combattre la crise du subprime aura-t-il été celui prêté à l’ancien dirigeant Mikhaël Gorbatchev. Analysant en 2008 cette profusion d’interventions publiques pour sauver des grandes banques en faillite, tandis qu’on laissait les surendettés se faire expulser..

Hoerl & McCormack propose that animals learn sequences through an entrainment-like process, rather than tracking the temporal addresses of each event in a given sequence. However, past research suggests that animals form “temporal maps” of sequential events and also comprehend the concept of ordinal position. These findings suggest that a clarification or qualification of the authors’ hypothesis is needed.

À chaque décennie, l’anniversaire de Mai 68 apporte son lot de confusion supplémentaire à qui veut tenter de donner un sens à l’événement1. Le quarantième anniversaire ne change rien à la chose, même si Mai, faisant désormais parti du paysage historique et mémoriel, donne naissance à un réexamen historiographique plus conséquent2. Pourtant, à quelques rares exceptions, cette..

Comment évolue depuis quelques années la démocratie en Occident ? C’est au fond à cette question essentielle que sont consacrés les textes proposés ici par la section « Vie politique ». Même si la mort de Ben Laden, en mai dernier, a pu laisser penser que l’Amérique d’Obama avait retrouvé une certaine confiance en elle, le berceau de la démocratie n’en est pas..

Several highly disregarded but important facts about linguistic performance constIain possible theories on general form in lexical entIies. Even semantic theories where these facts can be accomodatedremain undeveloped in this area. Taking advantage as a heuristic resource of a logical concept traceable to Hilbert a rational reconstIuction of lexical learning can be advanced, from which it is derived a first version of the general form of lexical entIies. An extension on the procedure allows development of an improved version. Under some (...) natural assumptions the final proposal accounts for the problematic facts. It is suggested that the heuristic and possible explanatory power of this approach be tested on some semantical topics currently discussed. (shrink)

Comment évolue depuis quelques années la démocratie en Occident? C’est au fond à cette question essentielle que sont consacrés les textes proposés ici par la section « Vie politique ». Même si la mort de Ben Laden, en mai dernier, a pu laisser penser que l’Amérique d’Obama avait retrouvé une certaine confiance en elle, le berceau de la démocratie n’en est pas...

This is a well-written and interesting little book about a long and meandering letter drafted around 1067 by the great Christian reformer St. Peter Damian. It concerns the question of whether or not God can change the past. The letter is addressed to Desiderius, abbot of Monte Cassino and later Pope Victor III, but the object of Damian's concern apparently is certain dialecticians, possibly Berengar of Tours or Anselm of Besate, who put too great a stress on the capacity of (...) reason to grasp truth independently of Scripture. (shrink)

Both as regards their compass (non-other-addressed speech and non-informative communication are in effect ignored) and their scarcely empirical nature, there is reason to be dissatisfied with recent developments in Pragmatics. How to find a sounder basis for pragmatic investigation? If a psychological (in this sense: centered on underlying mental processes) appproach is adopted in Pragmatics investigation, a strategic detour through mental processes leading to other kinds of activities is likely to prove methodologically sound and heuristically fruitful. For it allows outlining (...) an abstract model of (mental processes) inception of any kind of activity, keeping so at bay theoretical bias from the particular pragmatic standpoint that the theorist may happen to favor. And filling in the model with the specific features of language use shows promise to provide more specific models of the psychological processes underlying performance of linguistic activities. (shrink)

Both as regards their compass (non-other-addressed speech and non-informative communication are in effect ignored) and their scarcely empirical nature, there is reason to be dissatisfied with recent developments in Pragmatics. How to find a sounder basis for pragmatic investigation? If a psychological (in this sense: centered on underlying mental processes) appproach is adopted in Pragmatics investigation, a strategic detour through mental processes leading to other kinds of activities is likely to prove methodologically sound and heuristically fruitful. For it allows outlining (...) an abstract model of (mental processes) inception of any kind of activity, keeping so at bay theoretical bias from the particular pragmatic standpoint that the theorist may happen to favor. And filling in the model with the specific features of language use shows promise to provide more specific models of the psychological processes underlying performance of linguistic activities. (shrink)

This paper addresses first the appticability of the main notions included in the general notion meant item, meant partial situation (MPST), meant activity (MACT), and implicitly meant background situation (IMBST) -that of meant agent will be only mentioned in an aside-, plus the notion meaning activity (MNGACT). It will be shown that, when coupled to other notions, such as ‘ontological status’ of IMBST relative to the focussed (part of) current situation (FCST), as well as to the matching ‘ontological’ properties of (...) the meant items above, they allow to set up unified and apparently successful methods to explore important and debated pragmatic issues. Then their usefulness for research in the domain traditionally accorded to speech-act theory is put to (a preliminary) test; and finally the general processual sketch of linguistic activity advanced in the last Sections of P.I is carefully gauged as to its prospects regarding actual implementation of more specific processual sketches of both emission and reception linguistic activities. (shrink)

This paper addresses first the appticability of the main notions included in the general notion meant item, meant partial situation (MPST), meant activity (MACT), and implicitly meant background situation (IMBST) -that of meant agent will be only mentioned in an aside-, plus the notion meaning activity (MNGACT). It will be shown that, when coupled to other notions, such as ‘ontological status’ of IMBST relative to the focussed (part of) current situation (FCST), as well as to the matching ‘ontological’ properties of (...) the meant items above, they allow to set up unified and apparently successful methods to explore important and debated pragmatic issues. Then their usefulness for research in the domain traditionally accorded to speech-act theory is put to (a preliminary) test; and finally the general processual sketch of linguistic activity advanced in the last Sections of P.I is carefully gauged as to its prospects regarding actual implementation of more specific processual sketches of both emission and reception linguistic activities. (shrink)

Both as regards their compass (non-other-addressed speech and non-informative communication are in effect ignored) and their scarcely empirical nature, there is reason to be dissatisfied with recent developments in Pragmatics. How to find a sounder basis for pragmatic investigation? If a psychological (in this sense: centered on underlying mental processes) appproach is adopted in Pragmatics investigation, a strategic detour through mental processes leading to other kinds of activities is likely to prove methodologically sound and heuristically fruitful. For it allows outlining (...) an abstract model of (mental processes) inception of any kind of activity, keeping so at bay theoretical bias from the particular pragmatic standpoint that the theorist may happen to favor. And filling in the model with the specific features of language use shows promise to provide more specific models of the psychological processes underlying performance of linguistic activities. (shrink)

This final part of the essay begins by exploring some linguistic resources that organize the overall structure of utterances and longer stretches of discourse. Then specific study of emission is broached: after touching upon some further constraints and patterns of interpersonal behavior, the previously developed general sketch of (actionlike) activities’ inception is applied to several types of speech (soliloquy, full other-addressed speech and an intermediate type); the section ends with an assessment of results. Study of linguistic reception is prefaced by (...) a general sketch of processes occurring in perception-like activities, which is then specified for Iinguistic reception; on this basis alternative preferential interpretations of an example are delved into. After an appraisal of results and perspectives and a section on general (mainly methodological) conclusions, the essay comes to a close with several Appendixes. (shrink)

Before processual analyses of the activities of Iinguistic emission and reception are performed, a modicum of elaboration of the notions and technical devices previously suggested is necessary. First, theoretical resources previously developed are revised in two different fashions: some require to be elaborated in higher detail, while in other cases what is needed is to remove, at least in part, some restrictions initially laid down for simplification purposes. Then some notional clarifications and new specific distinctions a.nd notions are suggested for (...) the study of emission, since the fact that this kind of linguistic performance is all but ignored in traditional (psychological) Pragmatics calls for an attempt to dispel some confusions originating in such a virtual neglect, and, on the other hand, for creation of a suitable array of such theoretical tools. (shrink)

« La violence s’oppose si peu à la faiblesse que la faiblesse n’a souvent pas d’autre symptôme que la violence ; faible et brutale, et brutale parce que faible précisément. »Dans son ouvrage de référence, La civilisation des mœurs, Norbert Elias explique qu’au fil des siècles l’agressivité aurait été « maîtrisée »...

The European Commission’s proposal to address antimicrobial resistance using transferable exclusivity vouchers (TEVs) is fundamentally flawed. European policymakers and regulators should consider alternatives, such as better funding for basic and clinical research, use of advance market commitments funded by a pay-or-play tax, or enacting an EU Fund for Antibiotic Development.

But how is is that thought (viz., sense, imagination, and thought proper) is sometimes followed by action, sometimes not; sometimes by movement, sometimes not? What happens seems parallel to the case of thinking and inferring about the immovable objects of science. There the end is the truth seen (for, when one conceives the two premises, one at once conceives and comprehends the conclusion), but here the two premises result in a conclusion which is an action…Now that the action is the (...) conclusion is clear. But the premises of action are of two kinds, of the good and of the possible. Aristotle, De Motu Animalium, 701a, 6–10, 23–25. (shrink)